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SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin promotes cancer cell death
Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells.
Direct investigation of curcumin benefits
We explored the impact of curcumin, a natural compound found in turmeric, on non-small cell lung cancer (NSCLC). Our investigation utilized two models: laboratory-based NSCLC cell lines (A549 and NCI-H1299) and a mouse tumor model. By applying curcumin treatment, we aimed to understand how it influences cell growth and induces a specific form of cell death known as pyroptosis.
Our findings revealed that curcumin effectively slowed down the growth of NSCLC cells and triggered pyroptosis. This process is mediated through interactions with a protein called Smurf2, which regulates the ubiquitination of another protein, NLRP3. We observed that when Smurf2 activity was inhibited by curcumin, NLRP3 was stabilized, leading to increased levels of pyroptosis-associated factors.
In the animal study, curcumin treatment also resulted in smaller tumor sizes and decreased expression of Ki67, a marker for cell proliferation. Furthermore, this treatment increased NLRP3 and the factors linked to pyroptosis. Overall, our work illustrates how curcumin may hold therapeutic promise for lung cancer treatment by promoting destruction of cancer cells through pyroptosis.
Our findings revealed that curcumin effectively slowed down the growth of NSCLC cells and triggered pyroptosis. This process is mediated through interactions with a protein called Smurf2, which regulates the ubiquitination of another protein, NLRP3. We observed that when Smurf2 activity was inhibited by curcumin, NLRP3 was stabilized, leading to increased levels of pyroptosis-associated factors.
In the animal study, curcumin treatment also resulted in smaller tumor sizes and decreased expression of Ki67, a marker for cell proliferation. Furthermore, this treatment increased NLRP3 and the factors linked to pyroptosis. Overall, our work illustrates how curcumin may hold therapeutic promise for lung cancer treatment by promoting destruction of cancer cells through pyroptosis.
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8
Curcumin targets drug-resistant lung cancer
Evaluation of curcumin nanoparticles of various sizes for targeting multidrug-resistant lung cancer cells via inhalation.
Highly relevant therapeutic exploration
We explored how curcumin, a compound derived from turmeric, can be used to combat multidrug-resistant lung cancer through inhalation therapy. In our study, we focused on comparing small (30 nm) and larger (200 nm) nanoparticles of curcumin, nebulized to target resistant cancer cells known as H69AR.
Our findings revealed that the smaller curcumin nanoparticles led to significantly higher cell death in these lung cancer cells. This heightened effectiveness is attributed to their improved uptake into the cells, primarily through a specific cellular process known as dynamin-dependent clathrin-mediated endocytosis.
We further discovered that the smaller nanoparticles not only reached the desired cancer cells more effectively, but also triggered higher oxidative stress, resulting in greater mitochondrial dysfunction. The study also highlighted a reduction in a protein associated with drug resistance, suggesting that these curcumin nanoparticles could help in overcoming the resistance displayed by these cancer cells.
Overall, our research indicates that nebulized small curcumin nanoparticles hold promise for treating difficult lung cancers, showing a significant potential impact on how we approach targeted therapies for such conditions.
Our findings revealed that the smaller curcumin nanoparticles led to significantly higher cell death in these lung cancer cells. This heightened effectiveness is attributed to their improved uptake into the cells, primarily through a specific cellular process known as dynamin-dependent clathrin-mediated endocytosis.
We further discovered that the smaller nanoparticles not only reached the desired cancer cells more effectively, but also triggered higher oxidative stress, resulting in greater mitochondrial dysfunction. The study also highlighted a reduction in a protein associated with drug resistance, suggesting that these curcumin nanoparticles could help in overcoming the resistance displayed by these cancer cells.
Overall, our research indicates that nebulized small curcumin nanoparticles hold promise for treating difficult lung cancers, showing a significant potential impact on how we approach targeted therapies for such conditions.
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9
Curcumin via exosomes shows promise
Camel milk-derived exosomes as novel nanocarriers for curcumin delivery in lung cancer.
Directly addresses curcumin's effectiveness
We explored the potential of curcumin, a compound found in turmeric, as a treatment for non-small cell lung cancer (NSCLC) by utilizing camel milk-derived exosomes as delivery vehicles. Traditional treatments for lung cancer often face challenges, including side effects and drug resistance, prompting the search for more effective solutions.
The study involved isolating exosomes from camel milk and confirming their properties through various tests. We found that these exosomes could effectively encapsulate curcumin, achieving a 20% loading efficiency. When we tested the exosomal formulation of curcumin, known as ExoCUR, we observed a significant increase in cytotoxic effects against both sensitive and resistant lung cancer cells compared to free curcumin.
Moreover, our molecular studies indicated that curcumin interacts strongly with the epidermal growth factor receptor (EGFR), a key player in cancer progression. This interaction suggests that curcumin can interfere with vital cancer signaling pathways. Overall, our findings demonstrate that camel milk-derived exosomes offer a promising method for enhancing the delivery and effectiveness of curcumin, potentially overcoming some limitations of current cancer therapies.
The study involved isolating exosomes from camel milk and confirming their properties through various tests. We found that these exosomes could effectively encapsulate curcumin, achieving a 20% loading efficiency. When we tested the exosomal formulation of curcumin, known as ExoCUR, we observed a significant increase in cytotoxic effects against both sensitive and resistant lung cancer cells compared to free curcumin.
Moreover, our molecular studies indicated that curcumin interacts strongly with the epidermal growth factor receptor (EGFR), a key player in cancer progression. This interaction suggests that curcumin can interfere with vital cancer signaling pathways. Overall, our findings demonstrate that camel milk-derived exosomes offer a promising method for enhancing the delivery and effectiveness of curcumin, potentially overcoming some limitations of current cancer therapies.
Read More
Most Useful Reviews
9.5
In remission
Elizabeth B: Curcumin is known for its anti-cancer properties. I have been taking 2g (4 capsules) daily since shortly after my stage 4 lung cancer diagnosis a year ago. I went into remission within three months, and all my tumours have since disappeared. I have been in remission with no evidence of disease for eight months now.
Read More
7.5
Supports treatment
Antinflammatory properties: I appreciate how effective curcumin is. It really helps with my joints and cartilage while I undergo lung cancer therapy.
Read More
7.5
Reduced inflammation
Inflammation has reduced! Known for its anti-cancer and anti-inflammatory properties, this brand is quite good for lung cancer treatment!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.2
9
CU17 enhances Gemcitabine efficacy
Synergistic Anti-Cancer Activities of Curcumin Derivative CU17 Combined with Gemcitabine Against A549 Non-Small-Cell Lung Cancer Cells.
Moderate relevance due to focus
We explored the potential of a curcumin derivative, CU17, in enhancing the effectiveness of Gemcitabine (Gem) against lung cancer. The study examined how this combination therapy affects A549 non-small-cell lung cancer (NSCLC) cells in laboratory settings and in mouse models.
Our findings revealed that CU17 significantly increased the anti-cancer strength of Gem, leading to better control over cancer cell survival. This was achieved by prolonging the S phase of the cell cycle and inducing G2/M phase arrest, which involved proteins like p21 and p53. Furthermore, CU17 boosted the apoptotic effects of Gem by altering the balance of pro-apoptotic and anti-apoptotic factors.
Additionally, in the in vivo experiments, CU17 not only enhanced the anti-cancer effects of Gem but also reduced its toxicity to vital organs such as the liver, kidneys, and spleen. Overall, our research highlights CU17 as a promising chemosensitizer that could improve treatment outcomes for patients with NSCLC without significantly increasing the side effects of Gem.
Our findings revealed that CU17 significantly increased the anti-cancer strength of Gem, leading to better control over cancer cell survival. This was achieved by prolonging the S phase of the cell cycle and inducing G2/M phase arrest, which involved proteins like p21 and p53. Furthermore, CU17 boosted the apoptotic effects of Gem by altering the balance of pro-apoptotic and anti-apoptotic factors.
Additionally, in the in vivo experiments, CU17 not only enhanced the anti-cancer effects of Gem but also reduced its toxicity to vital organs such as the liver, kidneys, and spleen. Overall, our research highlights CU17 as a promising chemosensitizer that could improve treatment outcomes for patients with NSCLC without significantly increasing the side effects of Gem.
Read More
9
Curcumin promotes cancer cell death
Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells.
Direct investigation of curcumin benefits
We explored the impact of curcumin, a natural compound found in turmeric, on non-small cell lung cancer (NSCLC). Our investigation utilized two models: laboratory-based NSCLC cell lines (A549 and NCI-H1299) and a mouse tumor model. By applying curcumin treatment, we aimed to understand how it influences cell growth and induces a specific form of cell death known as pyroptosis.
Our findings revealed that curcumin effectively slowed down the growth of NSCLC cells and triggered pyroptosis. This process is mediated through interactions with a protein called Smurf2, which regulates the ubiquitination of another protein, NLRP3. We observed that when Smurf2 activity was inhibited by curcumin, NLRP3 was stabilized, leading to increased levels of pyroptosis-associated factors.
In the animal study, curcumin treatment also resulted in smaller tumor sizes and decreased expression of Ki67, a marker for cell proliferation. Furthermore, this treatment increased NLRP3 and the factors linked to pyroptosis. Overall, our work illustrates how curcumin may hold therapeutic promise for lung cancer treatment by promoting destruction of cancer cells through pyroptosis.
Our findings revealed that curcumin effectively slowed down the growth of NSCLC cells and triggered pyroptosis. This process is mediated through interactions with a protein called Smurf2, which regulates the ubiquitination of another protein, NLRP3. We observed that when Smurf2 activity was inhibited by curcumin, NLRP3 was stabilized, leading to increased levels of pyroptosis-associated factors.
In the animal study, curcumin treatment also resulted in smaller tumor sizes and decreased expression of Ki67, a marker for cell proliferation. Furthermore, this treatment increased NLRP3 and the factors linked to pyroptosis. Overall, our work illustrates how curcumin may hold therapeutic promise for lung cancer treatment by promoting destruction of cancer cells through pyroptosis.
Read More
9
Curcumin via exosomes shows promise
Camel milk-derived exosomes as novel nanocarriers for curcumin delivery in lung cancer.
Directly addresses curcumin's effectiveness
We explored the potential of curcumin, a compound found in turmeric, as a treatment for non-small cell lung cancer (NSCLC) by utilizing camel milk-derived exosomes as delivery vehicles. Traditional treatments for lung cancer often face challenges, including side effects and drug resistance, prompting the search for more effective solutions.
The study involved isolating exosomes from camel milk and confirming their properties through various tests. We found that these exosomes could effectively encapsulate curcumin, achieving a 20% loading efficiency. When we tested the exosomal formulation of curcumin, known as ExoCUR, we observed a significant increase in cytotoxic effects against both sensitive and resistant lung cancer cells compared to free curcumin.
Moreover, our molecular studies indicated that curcumin interacts strongly with the epidermal growth factor receptor (EGFR), a key player in cancer progression. This interaction suggests that curcumin can interfere with vital cancer signaling pathways. Overall, our findings demonstrate that camel milk-derived exosomes offer a promising method for enhancing the delivery and effectiveness of curcumin, potentially overcoming some limitations of current cancer therapies.
The study involved isolating exosomes from camel milk and confirming their properties through various tests. We found that these exosomes could effectively encapsulate curcumin, achieving a 20% loading efficiency. When we tested the exosomal formulation of curcumin, known as ExoCUR, we observed a significant increase in cytotoxic effects against both sensitive and resistant lung cancer cells compared to free curcumin.
Moreover, our molecular studies indicated that curcumin interacts strongly with the epidermal growth factor receptor (EGFR), a key player in cancer progression. This interaction suggests that curcumin can interfere with vital cancer signaling pathways. Overall, our findings demonstrate that camel milk-derived exosomes offer a promising method for enhancing the delivery and effectiveness of curcumin, potentially overcoming some limitations of current cancer therapies.
Read More
9
Lung cancer treatment via turmeric
Structural characterization of rhamnogalacturonan-I purified from and its anti-lung cancer efficacy via immunostimulation.
Significant focus on turmeric's effects
Our investigation focused on the structural characteristics and potential cancer-fighting abilities of a specific polysaccharide derived from turmeric, identified as TPE-I. We observed that TPE-I has a distinct structure similar to a well-known type of pectin called rhamnogalacturonan-I (RG-I).
Through our experiments, we found that TPE-I not only affected the immune response but also showed promising anti-cancer effects specifically against lung cancer. Notably, when we administered TPE-I, it enhanced the capacity of important immune cells, like natural killer (NK) cells and cytotoxic T lymphocytes, to attack tumor cells effectively.
Interestingly, even when we blocked NK cell function in mice, the positive effects of TPE-I in inhibiting lung cancer continued. This suggests that TPE-I operates through mechanisms beyond just NK cell activity. Our findings highlight that turmeric contains not only curcuminoids—commonly known for their health benefits—but also other bioactive compounds that might play crucial roles in cancer treatment.
Through our experiments, we found that TPE-I not only affected the immune response but also showed promising anti-cancer effects specifically against lung cancer. Notably, when we administered TPE-I, it enhanced the capacity of important immune cells, like natural killer (NK) cells and cytotoxic T lymphocytes, to attack tumor cells effectively.
Interestingly, even when we blocked NK cell function in mice, the positive effects of TPE-I in inhibiting lung cancer continued. This suggests that TPE-I operates through mechanisms beyond just NK cell activity. Our findings highlight that turmeric contains not only curcuminoids—commonly known for their health benefits—but also other bioactive compounds that might play crucial roles in cancer treatment.
Read More
9
Curcumin shows promise against lung cancer
Liposomal encapsulated curcumin attenuates lung cancer proliferation, migration, and induces apoptosis.
High relevance to lung cancer treatment
This study explored the potential of curcumin, a natural compound from turmeric, as a treatment for lung cancer, particularly focusing on non-small cell lung cancer (NSCLC). We examined how curcumin-loaded liposomes, specifically the formulation called PlexoZome®, affect A549 human lung adenocarcinoma cells.
Our findings were quite promising. The use of liposomal curcumin significantly reduced the proliferation and migration of these cancer cells. We also noted a marked decrease in the expression of several cancer marker proteins, which suggests that this treatment could hinder cancer development and spread.
The encapsulation of curcumin in liposomes appears to enhance its effectiveness, potentially addressing the issue of poor solubility and bioavailability commonly associated with curcumin. This research paves the way for developing a novel therapeutic option for patients battling NSCLC, highlighting curcumin's role as a valuable phytochemical in cancer treatment.
Our findings were quite promising. The use of liposomal curcumin significantly reduced the proliferation and migration of these cancer cells. We also noted a marked decrease in the expression of several cancer marker proteins, which suggests that this treatment could hinder cancer development and spread.
The encapsulation of curcumin in liposomes appears to enhance its effectiveness, potentially addressing the issue of poor solubility and bioavailability commonly associated with curcumin. This research paves the way for developing a novel therapeutic option for patients battling NSCLC, highlighting curcumin's role as a valuable phytochemical in cancer treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
In remission
Elizabeth B: Curcumin is known for its anti-cancer properties. I have been taking 2g (4 capsules) daily since shortly after my stage 4 lung cancer diagnosis a year ago. I went into remission within three months, and all my tumours have since disappeared. I have been in remission with no evidence of disease for eight months now.
Read More
8
May prevent cancer
Regular consumption of curcumin, as an antioxidant, may help prevent lung cancer.
7.5
Supports treatment
Antinflammatory properties: I appreciate how effective curcumin is. It really helps with my joints and cartilage while I undergo lung cancer therapy.
7.5
Reduced inflammation
Inflammation has reduced! Known for its anti-cancer and anti-inflammatory properties, this brand is quite good for lung cancer treatment!
4.5
No noticeable effect
I bought it because curcumin is said to be beneficial for lung cancer and immunity, but I haven’t noticed any effect, so I won't purchase it again.
